A Novel Elevated Plus-Maze Procedure to Avoid the One-Trial Tolerance Problem
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منابع مشابه
A Novel Elevated Plus-Maze Procedure to Avoid the One-Trial Tolerance Problem
The elevated plus-maze (EPM) test is one of the most commonly used behavioral assays to evaluate anxiety-related behavior in rodents. It is an economic test (5 min duration) without prior conditioning of the animals. The critical measure for anxiety is the time spent in the open arms of the maze. A confounding problem of the EPM is the so called one-trial tolerance (OTT), characterized by a mar...
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Although the mouse genome is now completely sequenced, the functions of most of the genes expressed in the brain are not known. The influence of a given gene on a specific behavior can be determined by behavioral analysis of mutant mice. If a target gene is expressed in the brain, behavioral phenotype of the mutant mice could elucidate the genetic mechanism of normal behaviors. The elevated plu...
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Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
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متن کاملUse of the elevated plus maze in the search for novel anxiolytic agents.
The elevated plus maze test is a rodent model of anxiety that is used extensively in the discovery of novel anxiolytic agents and to investigate the psychological and neurochemical basis of anxiety. The model is based on Montgomery's 1 observation that rats spent less time exploring the 'open' arms of a novel 'Y'-shaped elevated maze than an enclosed arm. The elevated plus maze used today 2 is ...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2011
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2011.00043